In a statement, the US Africa Command (USAFRICOM) said that the air strike, which took place on Thursday, was coordinated with the Libyan Government of National Accord (GNA).
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The military and foreign ministry in Israel, which has long accused Khartoum of serving as a base for militants from the Palestinian Islamist group Hamas, refused to comment.
The first strike hit north of Beit Hanun, critically wounding four Qassam Brigades militants, one of whom later died of his injuries, medics and the militant group said.
Fires and explosions rang out from Wadi Deif base in Maaret al-Numan
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